学科带头人：陈联国 研究员 

　　学科组研究生：唐丽珠，刘梦圆，孙佰丽，黄梓棱 

　　学科组介绍：本学科组围绕水生态毒理领域的重大环境安全问题，以水生生物为研究对象，对环境典型和新型持久性有机污染物的环境污染水平、毒理效应、作用机理与毒性控制技术展开深入的研究，为化学品的生态风险评价和安全使用管理提供数据支持。 

　　学科组重点关注：（1）揭示持久性有毒物质引起的生长发育、内分泌干扰、神经发育、生殖损伤、表观遗传及微生物失调等方面的毒性效应和分子机制；（2）探究污染物在生物体内的结合靶点，明确主要毒性效应的分子起始事件；（3）阐释污染物母代暴露引起子代健康危害以及表观遗传学改变的普遍规律；（4）围绕益生菌和益生元，开发污染物毒性危害控制技术。 

　　近年来学科组以第一或通讯作者发表SCI论文43篇（IF>3），其中在Environmental Science & Technology发表9篇，Environmental Science & Technology Letters发表1篇。研究成果受到美国Environmental Health News、新华社、中科院之声等科学媒体的关注和报导，并被挪威环保局采用、作为风险评估的主要数据。 

　　学科组长入选中科院引才计划青年项目、湖北省引才计划青年项目、湖北省青年科技晨光计划、武汉市黄鹤英才等人才计划，并获得香港科技大学理学院Research Excellence Award与教育部自然科学二等奖，现担任中国毒理学会分析毒理专业委员会青年委员，主持国家自然科学基金面上项目、青年基金、国际合作项目、中科院知识创新工程青年人才专项等研究任务。 

　　代表性论文：^#共同第一作者；*通讯作者 

　　1. Chen, L.,* Lam, J.C.W., Tang, L., Hu, C., Liu, M., Lam, P.K.S., Zhou, B.* Probiotic modulation of lipid metabolism disorders caused by perfluorobutanesulfonate pollution in zebrafish. Environmental Science & Technology 2020, 54, 7494？7503. 

　　2. Chen, L.,* Tsui, M.M.P., Hu, C., Wan, T., Au, D.W.T., Lam, J.C.W., Lam, P.K.S., Zhou, B. Parental exposure to perfluorobutanesulfonate impairs offspring development through inheritance of paternal methylome. Environmental Science & Technology 2019, 53, 12018？12025. 

　　3. Chen, L.,* Lam, J.C.W., Hu, C., Tsui, M.M.P., Lam, P.K.S., Zhou, B. Perfluorobutanesulfonate exposure skews sex ratio in fish and transgenerationally impairs reproduction. Environmental Science & Technology 2019, 53, 8389？8397. 

　　4. Chen, L., Hu, C., Tsui, M.M.P., Wan, T., Peterson, D.R., Shi, Q., Lam, P.K.S., Au, D.W.T., Lam, J.C.W.,* Zhou, B.* Multigenerational disruption of the thyroid endocrine system in marine medaka after a life-cycle exposure to perfluorobutanesulfonate. Environmental Science & Technology 2018, 52, 4432–4439. 

　　5. Chen, L., Zhang, W.,^# Hua, J., Hu, C., Lai, N.L.S., Qian, P.Y., Lam, P.K.S., Lam, J.C.W.,* Zhou, B.* Dysregulation of intestinal health by environmental pollutants: Involvement of the estrogen receptor and aryl hydrocarbon receptor. Environmental Science & Technology 2018, 52, 2323–2330.  

　　6. Chen, L., Au, D.W.T., Hu, C., Peterson, D.R., Zhou, B.,* Qian, P.Y.* Identification of molecular targets for 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one (DCOIT) in teleosts: New insight into mechanism of toxicity. Environmental Science & Technology 2017, 51, 1840–1847. 

　　7. Chen, L., Zhang, W., Ye, R., Hu, C., Wang, Q., Seemann, F., Au, D.W.T., Zhou, B., Giesy, J.P., Qian, P.Y.* Chronic exposure of marine medaka (Oryzias melastigma) to 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one (DCOIT) reveals its mechanism of action in endocrine disruption via the hypothalamus-pituitary-gonadal-liver (HPGL) axis. Environmental Science & Technology 2016, 50, 4492–4501. 

　　8. Chen, L., Sun, J.,^# Zhang, H., Au, D.W.T., Lam, P.K.S., Zhang, W., Bajic, V.B., Qiu, J.W., Qian, P.Y.* Hepatic proteomic responses in marine medaka (Oryzias melastigma) chronically exposed to antifouling compound butenolide [5-octylfuran-2(5H)-one] or 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one (DCOIT). Environmental Science & Technology 2015, 49, 1851–1859. 

　　9. Chen, L., Yu, K.,^# Huang, C., Yu, L., Zhu, B., Lam, P.K.S., Lam, J.C.W.,* Zhou, B.* Prenatal transfer of polybrominated diphenyl ethers (PBDEs) results in developmental neurotoxicity in zebrafish larvae. Environmental Science & Technology 2012, 46, 9727–9734. 

　　10. Chen, L.,* Lam, J.C.W., Hu, C., Tsui, M.M.P., Wang, Q., Giesy, J.P., Lam, P.K.S. Perfluorobutanesulfonate exposure causes durable and transgenerational dysbiosis of gut microbiota in marine medaka. Environmental Science & Technology Letters 2018, 5, 731–738. 

　　11. Chen, L.* Visual system: an understudied target of aquatic toxicology. Aquatic Toxicology 2020, 225, 105542. 

　　12. Chen, L.,* Lam, J.C.W. SeaNine 211 as antifouling biocide: A coastal pollutant of emerging concern. Journal of Environmental Sciences 2017, 61, 68–79.