水生生物分子与细胞生物学研究中心

鱼类分子免疫学学科组(中心主任代管)

 

  学科组成员:李顺助理研究员、陈丹丹实验师、王标实验助理    

  访问学者:马瑜副研究员、杨移斌助理研究员  

  在读博士生:陆龙凤、张向阳、王朝溪、李宪美  

  在读硕士生:崔正伟、药园园、王  鹏、周园园  

  本科实习生:杜思琦(武汉大学)、付思喆(武汉大学)、张子凌(华中农业大学)  

  毕业研究生:张旭杰博士、张弩博士、郭霞硕士  

  学科组介绍:  

  主要从基因、蛋白和细胞水平探索鱼类免疫系统的防御机制,并将其用于鱼类病害预防药物的研发以及与高等脊椎动物免疫系统的比较研究中。目前的研究工作主要有3个方面:(1)鱼类免疫反应的应用基础研究,主要从免疫学基础理论研究入手来揭示鱼类免疫反应的分子生物学与细胞生物学机理;(2)鱼类主要病害的免疫预防研究,主要包括针对经济鱼类主要疾病的疫苗、佐剂以及免疫增强剂的研发;(3)发育与比较免疫学的理论研究,主要结合发育生物学与比较生物学的方法来研究脊椎动物免疫系统的个体发育与系统进化。   

  近期发表文章:         

  1. Li S, Lu L F, Wang Z X, Lu X B, Chen D D, Nie P & Zhang Y A*. The P Protein of Spring Viremia of Carp Virus Negatively Regulates Fish IFN Response by Inhibiting the Kinase Activity of TANK-binding kinase 1. Journal of Virology 2016, 90 (23). (*通讯作者) (In Press) 

  2. Li S, Lu L F, LaPatra S E, Chen D D & Zhang Y A*. Zebrafish STAT6 negatively regulates IFNφ1 production by attenuating the kinase activity of TANK-binding kinase 1. Developmental and Comparative Immunology http://dx.doi.org/10.1016/j.dci.2016.10.003. (*通讯作者) (In Press) 

  3.Wu N, Song Y L, Wang B, Zhang X Y, Zhang X J, Wang Y L, Cheng Y Y, Chen D D, Xia X Q, Lu Y S & Zhang Y A*. Fish gut-liver immunity during homeostasis or inflammation revealed by integrative transcriptome and proteome studies. Scientific Reports 2016, 6: 36048; doi: 10.1038/srep36048. (*通讯作者) 

  4.Li S, Lu L F, Wang Z X, Chen D D & Zhang Y A*. Fish IRF6 is a positive regulator of IFN expression and involved in both of the MyD88 and TBK1 pathways. Fish & Shellfish Immunology 2016, 57: 262-268. (*通讯作者) 

  5. Lu L F, Li S, Lu X B, Scott E L, Zhang N, Zhang X J, Chen D D, Nie P & Zhang Y A*. Spring viremia of carp virus N protein suppresses fish IFNφ1 production by targeting the mitochondrial antiviral signaling protein. Journal of Immunology 2016, 196 (9): 3744-3753. (*通讯作者) 

  6. Zhang N, Zhang X J, Song Y L, Lu X B, Chen D D, Xia X Q, Sunyer J O & Zhang Y A*. Preferential combination between the light and heavy chain isotypes of fish immunoglobulins. Developmental & Comparative Immunology 2016, 61: 169-179. (*通讯作者) 

  7.Guo X, Chen D D, Peng K S, Cui Z W, Zhang X J, Li S & Zhang Y A*. Identification and characterization of Bacillus subtilis from grass carp (Ctenopharynodon idellus) for use as probiotic additives in aquatic feed. Fish & Shellfish Immunology 2016, 52: 74-84. (*通讯作者) 

  8. Zhang X J, Zhang X Y, Zhang N, Guo X, Peng K S, Wu H, Lu L F, Wu N, Chen D D, Li S, Nie P & Zhang Y A*. Distinctive structural hallmarks and biological activities of the multiple cathelicidin antimicrobial peptides in a primitive teleost fish. Journal of Immunology 2015, 194 (10): 4974-4987. (*通讯作者) 

  9. Li S, Guo X, Lu L F, Lu X B, Wu N & Zhang Y A*. Regulation pattern of fish irf4 (the gene encoding IFN regulatory factor 4) by STAT6, c-Rel and IRF4. Developmental & Comparative Immunology 2015, 51 (1): 65-73. (*通讯作者) 

  10. Wu N, Zhang X Y, Huang B, Zhang N, Zhang X J, Guo X, Chen X L, Zhang Y, Wu H, Li S, Li A H & Zhang Y A*. Investigating the potential immune role of fish NCAMs: molecular cloning and expression analysis in mandarin fish. Fish & Shellfish Immunology 2015,46 (2): 765-777. (*通讯作者) 

  11. Lu L F, Li S, Lu X B & Zhang Y A*. Functions of the two zebrafish MAVS variants are opposite in the induction of IFN1 by targeting IRF7. Fish & Shellfish Immunology 2015, 45 (2): 574-582. (*通讯作者) 

  12. Li S, Lu L F, Feng H, Wu N, Chen D D, Zhang Y B, Gui J F, Nie P & Zhang Y A*. IFN regulatory factor 10 is a negative regulator of the IFN responses in fish. Journal of Immunology 2014, 193 (3): 1100-1109. (*通讯作者) 

  13. Wu N, LaPatra S E, Li J, Sunyer J O* & Zhang Y A*. Complement C5a acts as molecular adjuvant in fish by enhancing antibody response to soluble antigen. Fish & Shellfish Immunology 2014, 40 (2): 616-623. (*共同通讯作者) 

  14. Zhang Y-A&, Salinas I& & Sunyer J O*. Recent findings on the structure and function of teleost IgT. Fish & Shellfish Immunology 2011, 31 (5): 627-634. (&共同第一作者) 

  15. Salinas I&, Zhang Y-A& & Sunyer J O*. Mucosal immunoglobulins and B cells in teleost fish. Developmental & Comparative Immunology 2011, 35 (12): 1346-1365. (&共同第一作者) 

  16. Zhang Y-A&, Salinas I&, Li J, Parra D, Bjork S J, Xu Z, LaPatra S E, Bartholomew J L & Sunyer J O*. IgT, a primitive immunoglobulin class specialized in mucosal immunity. Nature Immunology 2010, 11 (9): 827-835. (&共同第一作者) 

  17. Zhang Y-A&, Hikima J-I&, Li J, LaPatra S E, Luo Y-P & Sunyer J O*. Conservation of structural and functional features in a primordial CD80/86 molecule from rainbow trout (Oncorhynchus mykiss), a primitive teleost fish. Journal of Immunology 2009, 183 (1): 83-96. (&共同第一作者) 

    荣誉:    

  张永安,2012年获得中共中央湖北省委“湖北省特聘专家”称号。 

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