鱼类发育遗传学与细胞工程学学科组
学科带头人：桂建芳 院士
学科组成员： 周莉博士，研究员；王忠卫博士，研究员；童金苟博士，研究员；汪洋博士，副研究员；李熙银博士，副研究员；李志，高级实验师；张晓娟，实验师
学科组介绍：该学科组现得到国家重点研发计划、国家自然科学基金重点项目和面上项目、现代农业产业技术体系、中国科学院战略性科技先导专项、中国科学院前沿科学重点研究项目、淡水生态与生物技术国家重点实验室自主研究项目等支持。
研究工作主要集中在三个方面，一是进行鱼类重要经济性状的遗传基础解析，重点关注银鲫配子发生和雌核生殖、性别决定和分化、免疫和抗病以及金鱼形态变异的分子机制，发展性别控制和基因编辑育种技术；二是进行多倍体鱼类基因组融合重构和解析，试图揭示基因组或亚基因组整入如何创制新种质导致养殖鱼类经济性状改良的遗传机制，由此开拓新的多倍化和单性育种的技术路线；三是进行水产养殖动物新品种培育和示范推广，创制优异种质，发展并应用全基因组选择、基因组融合重构、基因编辑、性别控制等育种技术，培育高产、抗病（逆）、优质的水产养殖动物新品种，开展育成品种的示范推广和应用。
近3年主要代表作：
[1] Wang Y, Li XY, Xu WJ, Wang K, Wu B, Xu M, Chen Y, Miao LJ, Wang ZW, Li Z, Zhang XJ, Yin Z, Zhou BT, Yang YL, Zhu CL, Hu ML, Zheng JM, Feng CG, Qiu Q, Tian LT, Lu M, Peng F, Lu WJ, Tong JF, Tong JG, Fu BD, Yu P, Ding M, Gan RH, Zhang QQ, Jian JB, Zhang C, He WM, Yang W, Zhao ZC, Zhang QQ, Gao Q, Xu JY, Bai MZ, Zhang YP, Yang HM, Fang XD, Wang W, Zhou L, Gui JF. 2022. Comparative genome anatomy reveals evolutionary insights into a unique amphitriploid fish. Nat. Ecol. Evol., doi: 10.1038/s41559-022-01813-z
[2] Lu LF, Jiang JY, Du WX, Wang XL, Li ZC, Zhou XY, Zhang C, Mou CY, Chen DD, Li Z, Zhou L, Gui JF, Li XY, Li S. 2022. Fish female-biased gene cyp19a1a leads to female antiviral response attenuation between sexes by autophagic degradation of MITA. PLoS Pathog., 18: e1010626.
[3] Wang MT, Li Z, Ding M, Yao TZ, Yang S, Zhang XJ, Miao C, Du WX, Shi Q, Li S, Mei J, Wang Y, Wang ZW, Zhou L, Li XY, Gui JF. 2022. Two duplicated gsdf homeologs cooperatively regulate male differentiation by inhibiting cyp19a1a transcription in a hexaploid fish. PLoS Genet., 18(6):e1010288.
[4] Gui JF, Zhou L, Li XY. 2022. Rethinking fish biology and biotechnologies in the challenge era for burgeoning genome resources and strengthening food security. Water Biol. Secur., 1, 100002
[5] Gan RH, Wang Y, Li Z, Yu ZX, Li XY, Tong JF, Wang ZW, Zhang XJ, Zhou L, Gui JF. 2021. Functional divergence of multiple duplicated foxl2 homeologs and alleles in a recurrent polyploid fish. Mol Biol Evol., 38(5):1995-2013.
[6] Ding M, Li XY, Zhu ZX, Chen JH, Lu M, Shi Q, Wang Y, Li Z, Zhao X, Wang T, Du WX, Miao C, Yao TZ, Wang MT, Zhang XJ, Wang ZW, Zhou L, Gui JF. 2021. Genomic anatomy of male-specific microchromosomes in a gynogenetic fish. PLoS Genet., 17(9):e1009760.
[7] Lu M, Li XY, Li Z, Du WX, Zhou L, Wang Y, Zhang XJ, Wang ZW, Gui JF. 2021. Regain of sex determination system and sexual reproduction ability in a synthetic octoploid male fish. Sci China Life Sci., 64(1):77-87.
[8] Yu P, Wang Y, Yang WT, Li Z, Zhang XJ, Zhou L, Gui JF. 2021. Upregulation of the PPAR signaling pathway and accumulation of lipids are related to the morphological and structural transformation of the dragon-eye goldfish eye. Sci China Life Sci., 64(7):1031-1049.
[9] Zhou YL, Wang ZW, Guo XF, Wu JJ, Lu WJ, Zhou L, Gui JF. 2021. Construction of a high-density genetic linkage map and fine mapping of QTLs for growth and sex-related traits in red-tail catfish (Hemibagrus wyckioides). Aquaculture, 531, 735892.
[10] Wang T, Li Z, Yu ZX, Wang Z W, Lian ZQ, Du WX, Zhao X, Wang MT, Miao C, Ding M, Wang Y, Zhou L, Zhang XJ, Li XY, Gui JF. 2021. Production of YY males through self-fertilization of an occasional hermaphrodite in Lanzhou catfish (Silurus lanzhouensis). Aquaculture, 539:736622.
