学科组长：汪亚平 

　　学科组成员：廖兰杰 高级实验师；夏晓勤 研究员；黄容 副研究员；何利波 副研究员；吴南 副研究员；石米娟 助理研究员；李勇明实验师；程莹寅 实验师；张婉婷 实验师

　　主要研究方向

　　代表论文（* 通讯作者）： 

　　Genomes: 

　　[1]  Wang YP*, Lu Y, Zhang Y, Ning ZM, Li Y, Zhao Q, Lu HY, Huang R, Xia XQ, Feng Q, Liang XF, Liu KY, Zhang L, Lu TT, Huang T, Fan DL, Weng QJ, Zhu CR, Lu YQ, Li WJ, Wen ZR, Zhou CC, Tian QL, Kang XJ, Shi MJ, Zhang WT, Jang SH, Du FK, He S, Liao LJ, Li YM, Gui B, He HH, Ning Z, Yang C, He LB, Luo LF, Yang R, Luo Q, Liu XC, Li SS, Huang W, Xiao L, Lin HR*, Han B*, Zhu ZY*. The draft genome of the grass carp (Ctenopharyngodon idellus) provides genomic insights into its evolution and vegetarian diet adaptation. Nature Genetics, 2015, 47: 625-631. 

　　[2] Huang R#, Shi M#, Luo L, Yang C, Ou M, Zhang W, Liao L, Li Y, Xia X, Zhu Z, Wang Y*. De novo screening of disease-resistant genes from the chromosome-level genome of rare minnow using CRISPR-cas9 random mutation. GigaScience, 2021, 10(11):giab075. 

　　[3] Ou M#, Huang R#, Yang C, Gui B, Luo Q, Zhao J, Li Y, Liao L, Zhu Z, Wang Y*, Chen K*. Chromosome-level genome assemblies of Channa argus and Channa maculata and comparative analysis of their temperature adaptability. GigaScience, 2021; 10: 1-11. 

　　Tools and Databases: 

　　[4] Yang C#, Huang R*, Ou M, Gui B, Zhao J, He L, Li Y, Liao L, Chen K, Wang Y*. A rapid method of sex-marker discovery based on NGS and determination of the XX / XY sex-determination type in Channa maculate. Aquaculture, 2020; 528: 735499. 

　　[5] Aidi Zhang#, Rong Huang#, Liangming Chen, Lv Xiong, Libo He, Yongming Li, Lanjie Liao, Zuoyan Zhu, Yaping Wang*. Computational identification of Y-linked markers and genes in the grass carp genome by using a pool-and-sequence method. Scientific Reports 2017; 7(1): 8213. 

　　[6] Tang Q, Song Y, Shi M, Cheng Y, Zhang W, Xia X-Q*. Inferring the hosts of coronavirus using dual statistical models based on nucleotide composition. Scientific Reports, 2015, 5:17155. 

　　[7]   Duan Y, Zhang W, Cheng Y, Shi M*, Xia X-Q*. A systematic evaluation of bioinformatics tools for identification of long noncoding RNAs. RNA, 2021, 27: 80-98. 

　　[8]   Chen Y, Shi M, Zhang W, Cheng Y, Wang Y, Xia X-Q*. The Grass Carp Genome Database (GCGD): an online platform for genome features and annotations. Database, 2017, 2017:bax051. 

　　[9]   Chen Y#, Shi M#, Cheng Y, Zhang W, Tang Q*, Xia X-Q*. FVD: The fish-associated virus database. Infection, Genetics and Evolution, 2018, 58:23-26. 

　　Anti-virus and other diseases 

　　[10] He L#, Zhu D, Liang X, Li Y, Liao L, Yang C, Huang R, Zhu Z, Wang Y*. Multi-Omics Sequencing Provides Insights Into Age-Dependent Susceptibility of Grass Carp (Ctenopharyngodon idellus) to Reovirus. Frontiers in Immunology, 2022, Online. 

　　[11] Xie J#, Li M#, Ye W, Shan J, Zhao X, Duan Y, Liu Y, Unger BH, Cheng Y, Zhang W, Wu N*, Xia X-Q*. Sinomenine hydrochloride ameliorates fish foodborne enteritis via α7nAchR mediated anti-inflammatory effect whilst altering microbiota composition. Frontiers in Immunology, 2021, 12: 766845. 

　　[12] Li M#, Zhao X#, Xie J, Tong X, Shan J, Shi M, Wang G, Ye W, Liu Y, Unger BH, Cheng Y, Zhang W, Wu N*, Xia X-Q*. Dietary Inclusion of Seabuckthorn (Hippophae rhamnoides) Mitigates Foodborne Enteritis in Zebrafish Through the Gut-Liver Immune Axis. Frontiers in Physiology, 2022, 13:831226. 

　　[13] Chu P#，He L*，Huang R，Liao L，Li Y，Zhu Z，Hu W，Wang Y*. Autophagy Inhibits Grass Carp Reovirus (GCRV) Replication and Protects Ctenopharyngodon idella Kidney (CIK) Cells from Excessive Inflammatory Responses after GCRV Infection. Biomolecules, 2020, 10: 1296-1318. 

　　[14] Yangyu Li#, Rong Huang*, Liangming Chen, Yangyang Li, Yongming Li, Lanjie Liao, Libo He, Zuoyan Zhu, Yaping Wang. Characterization of SR-B2a and SR-B2b genes and their ability to promote GCRV infection in grass carp (Ctenopharyngodon idellus). Developmental & Comparative Immunology 2021; 124: 104202. 

　　[15] Liangming Chen#, Rong Huang*, Yangyang Li, Yongming Li, Lanjie Liao, Libo He, Zuoyan Zhu, Yaping Wang. Genome-wide identification, evolution of Krüppel-like factors (klfs) and their expressions during GCRV challenge in grass carp (Ctenopharyngodon idella). Developmental & Comparative Immunology 2021; 120: 104062. 

　　[16] Lv Xiong#, Libo He#, Lifei Luo, Yongming Li, Lanjie Liao, Rong Huang, Zuoyan Zhu, Yaping Wang*. Global and Complement Gene-Specific DNA Methylation in Grass Carp after Grass Carp Reovirus (GCRV) Infection. International Journal of Molecular Sciences 2018; 19: 1110-1123.  

　　Growth and other traits: 

　　[17] Shi M#, Luo H#, Zhang W, Jiang Y, Chen J, Cheng Y, Hu W*, Xia X-Q*. A genome-wide linkage map and QTL mapping for growth traits of Asian rice-field eel (Monopterus albus). Aquaculture, 2021, 536: 736394. 

　　[18] Huang X#, Jiang Y#, Zhang W, Cheng Y, Wang Y, Ma X, Duan Y, Xia L, Chen Y, Wu N, Shi M*, Xia X-Q*. Construction of a high-density genetic map and mapping of growth related QTLs in the grass carp (Ctenopharyngodon idellus). BMC Genomics, 2020, 21:313. 

　　[19] Ye W, Duan Y, Zhang W, Cheng Y, Shi M*, Xia X-Q*. Comprehensive analysis of hub mRNA, lncRNA and miRNA, and associated ceRNA networks implicated in grass carp (Ctenopharyngodon idella) growth traits. Genomics, 2021, 113(6): 4004-4014. 

　　[20] Rumana Mehjabin#, Lv Xiong, Rong Huang*, Cheng Yang, Geng Chen, Libo He, Lanjie Liao, Zuoyan Zhu, Yaping Wang*. Full-length transcriptome sequencing and the discovery of new transcripts in the unfertilized eggs of zebrafish (Danio rerio). G3: Genes, Genomes, Genetics 2019; 9(5): 1831-1838.  

　　[21] Lifei Luo#, Rong Huang#, Aidi Zhang, Cheng Yang, Liangming Chen, Denghui Zhu, Yongming Li, Libo He, Lanjie Liao, Zuoyan Zhu, Yaping Wang*. Selection of growth-related genes and dominant genotypes in transgenic yellow river carp Cyprinus carpio L. Functional & Integrative Genomics 2018; 18(4): 425-437. 

　　[22] Libo He#, Lv Xiong, Aidi Zhang, Yongming Li, Rong Huang, Lanjie Liao, Zuoyan Zhu, Yaping Wang*. Changes in gene and genotype frequencies during the development of the grass carp Ctenopharyngodon idella. Journal of fish biology 2018; 93:1113-1120.